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Download Resistance to Targeted ABC Transporters in Cancer by Thomas Efferth PDF

By Thomas Efferth

This severe overview quantity explores the subject of ABC transporters within the context of simple melanoma learn and its role in drug-resistant tumors. The chapters provided complement easy examine by means of including investigations from translational functions to scientific oncology. the improvement of resistance is a tremendous main issue in melanoma chemotherapy and the sector has been relocating swiftly when it comes to picking out the mechanisms for blocking ABC transporter-mediated drug efflux through particular inhibitors and thereby overcoming multidrug resistance. The volume covers those matters in cautious element. extra subject matters comprise the relevance of ABC transporters in resistance to novel and verified anticancer medications and analysis of sufferers to compounds, compounds utilized in photodynamic remedy, tyrosine kinase inhibitors and others. moreover, the possibility of radiopharmaceuticals for prognosis of multidrug-resistant tumors and of nanotechnology to strive against drug-resistant tumors is also discussed.

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