By Li Di,Edward H Kerns
The authors describe how houses have an effect on in vivo pharmacological task and influence in vitro assays. person drug-like houses are mentioned from a pragmatic standpoint, similar to solubility, permeability and metabolic balance, in regards to primary knowing, functions of estate facts in drug discovery and examples of structural alterations that experience completed superior estate functionality. The authors additionally assessment a number of equipment for the screening (high throughput), prognosis (medium throughput) and in-depth (low throughput) research of drug properties.
* Serves as an important operating instruction manual geared toward scientists and scholars in medicinal chemistry
* offers sensible, step by step suggestions on estate basics, results, structure-property relationships, and constitution amendment recommendations
* Discusses advancements in pharmacokinetics from a realistic chemist's standpoint
Read or Download Drug-like Properties: Concepts, Structure Design and Methods: from ADME to Toxicity Optimization PDF
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