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Download Copper-Catalyzed Multi-Component Reactions: Synthesis of by Yusuke Ohta PDF

By Yusuke Ohta

A copper-catalyzed direct synthesis of 2-(aminomethyl)indoles by way of catalytic domino response together with multi-component coupling used to be constructed, and is the 1st instance of a three-component indole formation with no generating salts as a byproduct. in line with this response, a copper-catalyzed synthesis of 3-(aminomethyl)isoquinoline was once entire which represents an unparalleled isoquinoline synthesis via a four-component coupling response. Following those effects, broad program reports utilizing one-pot palladium-, acid-, or base-promoted cyclization printed that indole- or isoquinoline-fused polycyclic compounds could be quite simply synthesized via multi-component reactions. because the proposal of eco-friendly Chemistry turns into ever extra vital, those findings could provide effective and atom-economical ways to the diversity-oriented synthesis of bioactive compounds containing a fancy constitution. this may bring about improvement of promising drug leads with structural complexity. The paintings of this thesis will move directly to encourage the factitious study of many readers.

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