Quantification of the proliferative features of ordinary and malignant cells has been of curiosity to oncolo­ gists and melanoma biologists for nearly 3 many years. This curiosity stems from (a) the truth that melanoma is a disorder of out of control proliferation, (b) the discovering that the various established anticancer brokers are preferentially poisonous to cells which are actively proliferating, and (c) the observa­ tion that major variations in proliferation features exist among basic and malignant cells. in the beginning, telephone cycle research used to be pursued enthusiastically within the wish of gener­ ating details helpful for the advance of rational melanoma treatment concepts; for instance, by way of permitting identi­ fication of swiftly proliferating tumors opposed to which phone cycle-specific brokers will be used with greatest effec­ tiveness and via permitting rational scheduling of mobilephone cyc- particular healing brokers to maximise the healing ratio. regrettably, a number of problems have avoided realiza­ tion of the early promise of mobile cycle research: Proliferative styles of the traditional and malignant tissues were came across to be considerably extra complicated than initially an­ ticipated, and synchronization of human tumors has proved remarkably tricky. Human tumors of an analogous style have proved hugely variable, and the cytokinetic instruments to be had for phone cycle research were hard work in depth, in addition to a bit of subjective and in lots of situations inapplicable to people. in spite of the fact that, the potential of considerably better melanoma treatment continues to be if extra exact cytokinetic infor­ mation approximately human malignancies and basic tissues could be got in a well timed fashion.