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Download Handbook of Solubility Data for Pharmaceuticals by Abolghasem Jouyban PDF

By Abolghasem Jouyban

Aqueous solubility is among the significant demanding situations within the early phases of drug discovery. some of the most universal and powerful tools for reinforcing solubility is the addition of an natural solvent to the aqueous resolution. besides an creation to cosolvency versions, the Handbook of Solubility information for Pharmaceuticals presents an in depth database of solubility for prescription drugs in mono solvents and binary solvents. Aqueous solubility info are available within the Handbook of Aqueous Solubility Data through Samuel Yalkowsky and Yan He. stopover at www.crcpress.com for additional information.



In addition to the experimental efforts to degree the solubility of gear in mono and combined solvents, this publication discusses the benefits and boundaries of a few mathematical types used to foretell the solubility in mono or combined solvent structures. It covers the pharmaceutical cosolvents and different natural solvents which are utilized in syntheses, separations, and different pharmaceutical approaches. The solutes featured comprise the to be had info for respectable medicines, drug applicants, precursors of gear, metabolites, and degradation items of prescription drugs. the writer additionally provides the solubilities of amino acids given that they play a major position in peptide drug properties.



Collecting drug solubilities in numerous cosolvents, this time-saving guide comprises the combos and version constants had to are expecting undetermined solubilities. It describes mathematical types that permit facts to be derived and gives estimates on how medicinal drugs tend to behave in a given cosolvent. A software and linked consumer guide can be found at the author’s website.


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